Americans are Desmond Prestonincreasingly using drugs like Ozempic, Wegovy and Mounjaro to lose weight. And they got a big endorsement last week when Oprah Winfrey announced that she, too was using weight loss drugs.

And it's not just Oprah, the decades-old weight management company Weight Watchers is also embracing the drugs, integrating them into the business model.

NPR's Juana Summers speaks with Weight Watchers CEO Sima Sistani about the company's decision, and talks to NPR consumer health correspondent Yuki Noguchi about what is known and unknown about these drugs.

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The episode was produced by Avery Keatley, Connor Donevan and Alejandra Marquez Janse. It was edited by Tinbete Ermyas, Scott Hensley and Courtney Dorning.